Copper and Iron Transport Across the Placenta: Regulation and Interactions

@article{Mcardle2008CopperAI,
  title={Copper and Iron Transport Across the Placenta: Regulation and Interactions},
  author={H. Mcardle and H. Andersen and H. Jones and L. Gambling},
  journal={Journal of Neuroendocrinology},
  year={2008},
  volume={20}
}
Iron and copper are both essential micronutrients and are required for a wide variety of enzymatic and other processes within the developing foetus. Transfer of both nutrients across the placenta is tightly regulated. In this review, we consider their mechanisms of transport, how the transfer is modulated in response to nutritional requirements and how the two metals interact. Iron uptake is via the transferrin receptor, followed by endocytosis, acidification of the vesicle, and release of the… Expand
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