Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships

  title={Copper and Human Health: Biochemistry, Genetics, and Strategies for Modeling Dose-response Relationships},
  author={B. Stern and M. Solioz and D. Krewski and P. Aggett and Tar-{\'C}hing Aw and S. Baker and K. Crump and M. Dourson and L. Haber and Rick Hertzberg and C. Keen and B. Meek and L. Rudenko and R. Schoeny and W. Slob and Tom Starr},
  journal={Journal of Toxicology and Environmental Health, Part B},
  pages={157 - 222}
  • B. Stern, M. Solioz, +13 authors Tom Starr
  • Published 2007
  • Biology, Medicine
  • Journal of Toxicology and Environmental Health, Part B
  • Copper (Cu) and its alloys are used extensively in domestic and industrial applications. Cu is also an essential element in mammalian nutrition. Since both copper deficiency and copper excess produce adverse health effects, the dose-response curve is U-shaped, although the precise form has not yet been well characterized. Many animal and human studies were conducted on copper to provide a rich database from which data suitable for modeling the dose-response relationship for copper may be… CONTINUE READING
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