Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein

@article{Fuerst1988CopperAM,
  title={Copper activates metallothionein gene transcription by altering the conformation of a specific DNA binding protein},
  author={Peter Fuerst and Stella L. Y. Hu and R H Hackett and Dean Hamer},
  journal={Cell},
  year={1988},
  volume={55},
  pages={705-717}
}
Copper homeostasis in yeast involves a copper binding protein, metallothionein, and a trans-acting regulatory protein that activates transcription of the metallothionein gene in response to copper ions. We show that the regulatory protein specifically binds to the metallothionein gene control sequences in the presence, but not in the absence, of copper. Both the DNA binding and metalloregulatory functions of the transacting factor are contained within its aminoterminal domain, and partial… CONTINUE READING

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