Copper activates TrkB in cortical neurons in a metalloproteinase-dependent manner.


Copper (Cu) is an endogenous metal that is physiologically essential in the brain and that, like zinc (Zn), may be synaptically released in certain regions. Previously, we demonstrated that Zn activates TrkB in cultured cortical neurons in a metalloproteinase (MP)-dependent manner. To determine whether Cu has similar properties, we exposed cortical cultures… (More)


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