It is highly attractive to develop non-noble-metal nanoarray architecture as a 3D-catalyst electrode for molecular detection due to its large specific surface area and easy accessibility to target molecules. Here, we report the development of a copper-nitride nanowires array on copper foam (Cu3 N NA/CF) as a dual-functional catalyst electrode for efficient glucose oxidation in alkaline solutions and hydrogen peroxide (H2 O2 ) reduction in neutral solutions. Electrochemical tests indicate that such Cu3 N NA/CF possesses superior non-enzymatic sensing ability toward rapid glucose and H2 O2 detection with high selectivity. At 0.40 V, this sensor offers a high sensitivity of 14 180 μA mm cm-2 for glucose detection, with a wide linear range from 1 μm to 2 mm, a low detection limit of 13 nm (S/N=3), and satisfactory stability and reproducibility. Its application in determining glucose in human blood serum is also demonstrated. Amperometric H2 O2 sensing can also been realized with a sensitivity of 7600 μA mm cm-2 , a linear range from 0.1 μm to 10 mm, and a detection limit of 8.9 nm (S/N=3). This 3D-nanoarray architecture holds great promise as an attractive sensing platform toward electrochemical small molecules detection.