Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.

@article{Shrestha2017CopperMC,
  title={Copper Mediated Coupling of 2-(Piperazine)-pyrimidine Iodides with Aryl Thiols using Cu(I)Thiophene-2-carboxylate.},
  author={Liza Shrestha and Hardik J. Patel and Yanlong Kang and Sahil Sharma and Gabriela Chiosis and Tony Taldone},
  journal={Tetrahedron letters},
  year={2017},
  volume={58 48},
  pages={
          4525-4531
        }
}
A copper-mediated synthesis of diaryl sulfides utilizing Cu(I)-thiophene-2-carboxylate (CuTC) is described. We demonstrate the use of CuTC as a soluble, non-basic catalyst in the coupling of aryl iodides and aryl thiols in the synthesis of synthetically advanced diaryl sulfides. This method allows for the successful coupling of challenging substrates… CONTINUE READING