Copper Complexes in the Promotion of Aldol Addition to Pyridine-2-carboxaldehyde: Synthesis of Homo- and Heteroleptic Complexes and Stereoselective Double Aldol Addition.

@article{lvarezMiguel2018CopperCI,
  title={Copper Complexes in the Promotion of Aldol Addition to Pyridine-2-carboxaldehyde: Synthesis of Homo- and Heteroleptic Complexes and Stereoselective Double Aldol Addition.},
  author={Luc{\'i}a {\'A}lvarez-Miguel and H{\'e}ctor Barbero and Adriana Sacrist{\'a}n-Mart{\'i}n and Jos{\'e} M Mart{\'i}n {\'A}lvarez and Alfonso P{\'e}rez-Encabo and Celedonio M {\'A}lvarez and Ra{\'u}l Garc{\'i}a-Rodr{\'i}guez and Daniel Miguel},
  journal={Inorganic chemistry},
  year={2018},
  volume={57 1},
  pages={264-276}
}
CuCl2·2H2O and Cu(ClO4)2·6H2O are able to promote aldol addition of pyridine-2-carboxaldehyde (pyca) with acetone, acetophenone, or cyclohexenone under neutral and mild conditions. The general and simple one-pot procedure for the aldol addition to Cu(II) complexes accesses novel Cu complexes with a large variety of different structural motifs, from which… CONTINUE READING