Copper-Catalyzed Radical Aminotrifluoromethylation of Alkenes.

@article{Xiao2019CopperCatalyzedRA,
  title={Copper-Catalyzed Radical Aminotrifluoromethylation of Alkenes.},
  author={Haiwen Xiao and Haigen Shen and Lin Zhu and Chaozhong Li},
  journal={Journal of the American Chemical Society},
  year={2019}
}
We report herein an unprecedented protocol for aminotrifluoromethylation of alkenes. With Cu(OTf)2 as the catalyst, the reaction of alkenes, (bpy)Zn(CF3)2 and N-fluorobis(benzenesulfonyl)imide (NFSI) at room temperature provides the corresponding aminotrifluoromethylation products in satisfactory yields with high regioselectivity opposite to those driven by CF3 radical addition. The method exhibits a broad sub-strate scope and wide functional group compatibility. A mechanism involving N-radical… CONTINUE READING

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