Copper-Catalyzed Denitrogenative Transannulation Reaction of Pyridotriazoles: Synthesis of Imidazo[1,5-a]pyridines with Amines and Amino Acids.

Abstract

The copper-catalyzed aerobic oxidative synthesis of imidazo[1,5-a]pyridines via cascade denitrogenative transannulation reaction of pyridotriazoles with benzylamines with good functional group tolerance is developed. The present methodology is also applicable to amino acids to obtain imidazo[1,5-a]pyridines via decarboxylative oxidative cyclization.

DOI: 10.1021/acs.orglett.5b03509

Cite this paper

@article{Joshi2016CopperCatalyzedDT, title={Copper-Catalyzed Denitrogenative Transannulation Reaction of Pyridotriazoles: Synthesis of Imidazo[1,5-a]pyridines with Amines and Amino Acids.}, author={Abhisek Joshi and D. Chandra Mohan and Subbarayappa Adimurthy}, journal={Organic letters}, year={2016}, volume={18 3}, pages={464-7} }