Copper(II)-catalyzed silyl conjugate addition to α,β-unsaturated conjugated compounds: Brønsted base-assisted activation of Si-B bond in water.

Abstract

A mild method for the installation of the dimethylphenylsilyl group on the β-carbon of electron-deficient olefins is reported. In the presence of a catalytic amount of copper(II) (1 mol %) and amine base (5 mol %) at rt, the transformation proceeds efficiently in water within 1.5-5 h to afford β-silylated products in yields of up to 90%. 
DOI: 10.1021/ol300618j

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Cite this paper

@article{Calderone2012CopperIIcatalyzedSC, title={Copper(II)-catalyzed silyl conjugate addition to α,β-unsaturated conjugated compounds: Br\onsted base-assisted activation of Si-B bond in water.}, author={Joseph A Calderone and Webster L Santos}, journal={Organic letters}, year={2012}, volume={14 8}, pages={2090-3} }