Copper‐Catalyzed Trifluoromethylation of Acrylamides Coupled with Indole Dearomatization: Access to Trifluoromethyl‐Substituted Spiro[indole‐3,3′‐pyrrolidine] Derivatives

@article{Han2016CopperCatalyzedTO,
  title={Copper‐Catalyzed Trifluoromethylation of Acrylamides Coupled with Indole Dearomatization: Access to Trifluoromethyl‐Substituted Spiro[indole‐3,3′‐pyrrolidine] Derivatives},
  author={Guifang Han and Qiang Wang and Linwei Chen and Yu‐Xin Liu and Qingmin Wang},
  journal={Advanced Synthesis \& Catalysis},
  year={2016},
  volume={358},
  pages={561-566}
}
A copper-catalyzed cascade reaction involving trifluoromethylation of acrylamides coupled with ring closure and indole dearomatization is reported. This facile transformation was highly regioselective and proceeded under mild conditions, allowing efficient access to trifluoromethyl-substituted spiro[indole-3,3′-pyrrolidine] derivatives, which are of increasing interest to the pharmaceutical industry. 
25 Citations
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