Copper, zinc-superoxide dismutase protects from ultraviolet B-induced apoptosis of SV40-transformed human keratinocytes: the protection is associated with the increased levels of antioxidant enzymes.

@article{Takahashi2000CopperZD,
  title={Copper, zinc-superoxide dismutase protects from ultraviolet B-induced apoptosis of SV40-transformed human keratinocytes: the protection is associated with the increased levels of antioxidant enzymes.},
  author={Hidetoshi Takahashi and Yoshio Hashimoto and Noriaki Aoki and Motoshi Kinouchi and Akemi Ishida-Yamamoto and Hajime Iizuka},
  journal={Journal of dermatological science},
  year={2000},
  volume={23 1},
  pages={12-21}
}
It has been reported that cellular oxidative stress induces apoptosis. Ultraviolet radiation that generates reactive oxygen intermediates (ROIs) also induces apoptosis. Superoxide dismutase (SOD) is among the most active scavengers of ROIs, providing defense against the cellular oxidative stress. Mammalian cells express two isozymes of SOD, copper, zinc-SOD (Cu, Zn-SOD) and manganese-SOD (Mn-SOD). Using SV40-transformed human keratinocytes (SVHK cells), we investigated the role of SODs in the… CONTINUE READING
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