Copper(II)-induced self-oligomerization of alpha-synuclein.

  title={Copper(II)-induced self-oligomerization of alpha-synuclein.},
  author={Seung R Paik and Hae Ja Shin and Jin Hee Lee and Chang-sheng S Chang and Jongsun Kim},
  journal={The Biochemical journal},
  volume={340 ( Pt 3)},
alpha-Synuclein is a component of the abnormal protein depositions in senile plaques and Lewy bodies of Alzheimer's disease (AD) and Parkinson's disease respectively. The protein was suggested to provide a possible nucleation centre for plaque formation in AD via selective interaction with amyloid beta/A4 protein (Abeta). We have shown previously that alpha-synuclein has experienced self-oligomerization when Abeta25-35 was present in an orientation-specific manner in the sequence. Here we… CONTINUE READING
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