Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.

@article{Komarnicka2016CopperICW,
  title={Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.},
  author={Urszula Katarzyna Komarnicka and Radosław Starosta and Michał A. Płotek and Rodrigo F. M. de Almeida and Małgorzata Jeżowska‐Bojczuk and Agnieszka Kyzioł},
  journal={Dalton transactions},
  year={2016},
  volume={45 12},
  pages={
          5052-63
        }
}
In this paper we present a first insight into the cytotoxic action mode of copper(I) iodide or copper(I) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rd generation fluoroquinolone antibiotic agent) and 2,9-dimethyl-1,10-phenanthroline or 2,2'-biquinoline as auxiliary ligands. The in vitro cytotoxic activity of the new complexes was tested against two cancer cell lines (CT26--mouse colon carcinoma and A549--human lung adenocarcinoma). An ICP-MS study revealed a marked… 
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The potential of the copper(I) complex 1 is promising though further in vivo investigations may be required before subjecting it to clinical trials.

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Interaction between DNA, Albumin and Apo-Transferrin and Iridium(III) Complexes with Phosphines Derived from Fluoroquinolones as a Potent Anticancer Drug

Fluorescence spectroscopic data provided evidence that Ir(III) complexes can bind to the proteins in order to be transferred, and molecular docking studies confirmed two binding modes: minor groove binding and threading intercalation with the fluoroquinolone part of the molecule involved in pi stacking interactions.

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The results ensure the role of thiosemicarbazone-based copper(i) complexes as prospective anticancer agents, induction of apoptosis and S phase arrest with the mitochondrial controlled pathway.

Anticancer, antimicrobial and antiparasitical activities of copper(I) complexes based on N-heterocyclic carbene (NHC) ligands bearing aryl substituents

Copper(I) complexes tested were the most active against MCF7 and MDA-MB-231 cancer cells, as well as the most potent antimicrobial against E. coli, MRSA and Candida albicans microorganisms, Leishmania major promastigotes and amastigote, Toxoplasma gondii parasites and against Vero cell line in vitro.

References

SHOWING 1-10 OF 60 REFERENCES

Copper(i) complexes with phosphine derived from sparfloxacin. Part I - structures, spectroscopic properties and cytotoxicity.

Results obtained showed that complexes with PPh2(CH2-Sf) are significantly more active than those with Dimine or phosphine derivatives of sparfloxacin, and the relative impact of diimine on cytotoxicity is less pronounced.

In vitro antitumor activity of the water soluble copper(I) complexes bearing the tris(hydroxymethyl)phosphine ligand.

Cytological stains and flow cytometric analyses indicated that the phosphine copper(I) complex is able to inhibit the growth of tumor cells via G2/M cell cycle arrest and paraptosis accompanied with the loss of mitochondrial transmembrane potential.

In vitro and in vivo anticancer activity of copper bis(thiosemicarbazone) complexes.

Neutral and cationic copper bis(thiosemicarbazone) complexes bearing methyl, phenyl, and hydrogen, on the diketo-backbone of the ligand have been synthesized and revealed that they are cytotoxic unlike the corresponding zinc complexes.

Copper(I) (Pseudo)Halide Complexes with Neocuproine and Aminomethylphosphines Derived from Morpholine and Thiomorpholine – In Vitro Cytotoxic and Antimicrobial Activity and the Interactions with DNA and Serum Albumins

Gel electrophoresis experiments demonstrated that all the compounds were comparably efficient in DNA degradation process; however, luminescence quenching showed surprising dependence on the interactions strength of the used compounds with the albumins.

In vitro and in vivo anticancer activity of copper(I) complexes with homoscorpionate tridentate tris(pyrazolyl)borate and auxiliary monodentate phosphine ligands.

The antitumor efficacy of complex 1 was validated in the murine Lewis Lung Carcinoma (LLC) model and morphology studies revealed an extensive cytoplasmic vacuolization coherently with a paraptosis-like cell death mechanism.

Oxidative stress induced by copper and iron complexes with 8-hydroxyquinoline derivatives causes paraptotic death of HeLa cancer cells.

The antiproliferative/cytotoxic properties of 8-hydroxyquinoline derivatives on HeLa cells in the presence of transition metal ions trigger a caspase-independent paraptotic process, which results from the induction of a severe oxidative stress and the unfolded protein response.

Interaction of Zn(II) with quinolone drugs: structure and biological evaluation.

The interaction of the Zn(II) complexes with human and bovine serum albumin proteins has been studied by fluorescence spectroscopy showing that the complexes exhibit good binding propensity to these proteins having relatively high binding constant values.

Coordination versatility of phosphine derivatives of fluoroquinolones. New CuI and CuII complexes and their interactions with DNA

In this paper, new copper(I) and copper(II) complexes with phosphine derivatives of two fluoroquinolones (ciprofloxacin and norfloxacin) are presented. The synthesized compounds ([CuI-PCp],…

Phosphine derivatives of sparfloxacin – Synthesis, structures and in vitro activity

Nickel-quinolones interaction. Part 4. Structure and biological evaluation of nickel(II)-enrofloxacin complexes compared to zinc(II) analogues.

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