Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.

@article{Komarnicka2016CopperICW,
  title={Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.},
  author={U. K. Komarnicka and R. Starosta and M. Płotek and R. D. de Almeida and M. Jeżowska‐Bojczuk and A. Kyzioł},
  journal={Dalton transactions},
  year={2016},
  volume={45 12},
  pages={
          5052-63
        }
}
In this paper we present a first insight into the cytotoxic action mode of copper(I) iodide or copper(I) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rd generation fluoroquinolone antibiotic agent) and 2,9-dimethyl-1,10-phenanthroline or 2,2'-biquinoline as auxiliary ligands. The in vitro cytotoxic activity of the new complexes was tested against two cancer cell lines (CT26--mouse colon carcinoma and A549--human lung adenocarcinoma). An ICP-MS study revealed a marked… Expand
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