Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.

  title={Copper(I) complexes with phosphine derived from sparfloxacin. Part II: a first insight into the cytotoxic action mode.},
  author={Urszula Katarzyna Komarnicka and Radosław Starosta and Michał A. Płotek and Rodrigo F. M. de Almeida and Małgorzata Jeżowska‐Bojczuk and Agnieszka Kyzioł},
  journal={Dalton transactions},
  volume={45 12},
In this paper we present a first insight into the cytotoxic action mode of copper(I) iodide or copper(I) thiocyanate complexes with a phosphine derivative of sparfloxacin (a 3rd generation fluoroquinolone antibiotic agent) and 2,9-dimethyl-1,10-phenanthroline or 2,2'-biquinoline as auxiliary ligands. The in vitro cytotoxic activity of the new complexes was tested against two cancer cell lines (CT26--mouse colon carcinoma and A549--human lung adenocarcinoma). An ICP-MS study revealed a marked… 

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