Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity.

@article{Greish2005CopolystyrenemaleicAM,
  title={Copoly(styrene-maleic acid)-pirarubicin micelles: high tumor-targeting efficiency with little toxicity.},
  author={Khaled Greish and Akinori Nagamitsu and Jun Fang and Hiroshi Maeda},
  journal={Bioconjugate chemistry},
  year={2005},
  volume={16 1},
  pages={
          230-6
        }
}
The copolymer of styrene-maleic acid (SMA) was used to construct micelles containing pirarubicin (4'-O-tetrahydropyranyladriamycin, or THP) as a new anticancer drug formulation. The procedure for the preparation of the micelles was simple, the component consisting of only SMA and pirarubicin in a noncovalent association, possibly by hydrophobic interaction between the styrene portion of SMA and pirarubicin chromophore. This method ensures more than 80% recovery of pirarubicin by weight, and 60… CONTINUE READING
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