Coping style and stress hormone responses in genetically heterogeneous rats: comparison with the Roman rat strains.

Abstract

The purpose of the present study was to evaluate for the first time the stress-induced hypothalamus-pituitary-adrenal (HPA), adrenocorticotropic hormone (ACTH), corticosterone and prolactin responses of the National Institutes of Health genetically heterogeneous rat stock (N/Nih-HS rats) in comparison with responses of the relatively high and low stress-prone Roman Low- (RLA-I) and High-Avoidance (RHA-I) rat strains. The same rats were also compared (experiment 1) with respect to their levels of unconditioned anxiety (elevated zero-maze test), novelty-induced exploratory behavior, conditioned fear and two-way active avoidance acquisition. In experiment 2, naive rats from these three strains/stocks were evaluated for "depressive-like" behavior in the forced swimming test. N/Nih-HS and RLA-I rats showed significantly higher post-stress ACTH, corticosterone and prolactin levels than RHA-I rats. N/Nih-HS rats also presented the highest context-conditioned freezing responses, extremely poor two-way avoidance acquisition and very low novelty-induced exploratory behavior. Experiment 2 showed that, compared to RHA-I rats, N/Nih-HS and RLA-I rats displayed significantly less struggling (escape-directed) and increased immobility responses in the forced swimming test. Factor analysis of data from experiment 1 showed associations among behavioral and hormonal responses, with a first factor comprising high loadings of elevated zero-maze variables and lower loadings of conditioned fear, two-way avoidance acquisition and hormonal measures, while a second factor mainly grouped conditioned fear and two-way avoidance acquisition with novelty-induced exploration and post-stress prolactin. Thus, regarding their anxiety/fearfulness, passive coping style, "depressive-like" and stress-induced hormonal responses the N/Nih-HS rats resemble the phenotype profiles of the relatively high-anxious and stress-prone RLA-I rat strain.

DOI: 10.1016/j.bbr.2011.12.002
05010020132014201520162017
Citations per Year

151 Citations

Semantic Scholar estimates that this publication has 151 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{DazMorn2012CopingSA, title={Coping style and stress hormone responses in genetically heterogeneous rats: comparison with the Roman rat strains.}, author={Sira D{\'i}az-Mor{\'a}n and Marta Pal{\`e}ncia and Carme Mont-Cardona and Toni Ca{\~n}ete and Gloria Bl{\'a}zquez and Esther Mart{\'i}nez-Membrives and Regina L{\'o}pez-Aumatell and Adolf Tobe{\~n}a and Alberto Fern{\'a}ndez-Teruel}, journal={Behavioural brain research}, year={2012}, volume={228 1}, pages={203-10} }