Coparalogy: physical and functional clusterings in the human genome.

  title={Coparalogy: physical and functional clusterings in the human genome.},
  author={Cornel Popovici and Magalie Leveugle and Daniel Birnbaum and François Coulier},
  journal={Biochemical and biophysical research communications},
  volume={288 2},
Two rounds of large-scale duplications are thought to have occurred in early vertebrate ancestry; this is now known as the "2R hypothesis." They have led to the constitution of subfamilies of paralogous genes. Chromosomal regions that contain present-day paralogs (paralogous regions or paralogons) have been identified in mammals. We show that sets of paralogons (PGs) can be assembled in a tentative "human genome paralogy map" that includes all autosomes and X. A total of 14 PGs, containing more… CONTINUE READING

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