• Medicine
  • Published in Cancer research 1982

Cooxidation of the clinical reagent 3,5,3'5'-tetramethylbenzidine by prostaglandin synthase.

@article{Josephy1982CooxidationOT,
  title={Cooxidation of the clinical reagent 3,5,3'5'-tetramethylbenzidine by prostaglandin synthase.},
  author={P. David Josephy and R. Preston Mason and Thomas E. Eling},
  journal={Cancer research},
  year={1982},
  volume={42 7},
  pages={
          2567-70
        }
}
Prostaglandin synthase catalyzes the oxidation of arachidonic acid to prostaglandin H2 via a hydroperoxide intermediate, prostaglandin G2. The prostaglandin synthase system cooxidizes 3,5,3'5'-tetramethylbenzidine (TMB), a derivative of the human carcinogen benzidine, to colored products. This process is arachidonic acid dependent and indomethacin sensitive. The reaction is also supported by hydroperoxides, and, in this case, indomethacin has no effect. This suggests that the cooxidation is… CONTINUE READING

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