Coordination of the transcriptome and metabolome by the circadian clock.

@article{EckelMahan2012CoordinationOT,
  title={Coordination of the transcriptome and metabolome by the circadian clock.},
  author={Kristin Eckel-Mahan and Vishal R. Patel and Robert P. Mohney and Katie S Vignola and Pierre Baldi and Paolo Sassone-Corsi},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 14},
  pages={
          5541-6
        }
}
The circadian clock governs a large array of physiological functions through the transcriptional control of a significant fraction of the genome. Disruption of the clock leads to metabolic disorders, including obesity and diabetes. As food is a potent zeitgeber (ZT) for peripheral clocks, metabolites are implicated as cellular transducers of circadian time for tissues such as the liver. From a comprehensive dataset of over 500 metabolites identified by mass spectrometry, we reveal the… CONTINUE READING

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