Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta.

@article{Liu2007CoordinationOS,
  title={Coordination of steps in single-nucleotide base excision repair mediated by apurinic/apyrimidinic endonuclease 1 and DNA polymerase beta.},
  author={Yuan Liu and Rajendra Prasad and William A. Beard and Padmini Kedar and Esther W. Hou and David D. Shock and Samuel H. Wilson},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 18},
  pages={13532-41}
}
The individual steps in single-nucleotide base excision repair (SN-BER) are coordinated to enable efficient repair without accumulation of cytotoxic DNA intermediates. The DNA transactions and various proteins involved in SN-BER of abasic sites are well known in mammalian systems. Yet, despite a wealth of information on SN-BER, the mechanism of step-by-step… CONTINUE READING