Coordination of size-control, reproduction and generational memory in freshwater planarians

  title={Coordination of size-control, reproduction and generational memory in freshwater planarians},
  author={Xingbo Yang and Kelson J. Kaj and David J. Schwab and Eva-Maria S. Collins},
  journal={Physical Biology},
Uncovering the mechanisms that control size, growth, and division rates of organisms reproducing through binary division means understanding basic principles of their life cycle. Recent work has focused on how division rates are regulated in bacteria and yeast, but this question has not yet been addressed in more complex, multicellular organisms. We have, over the course of several years, assembled a unique large-scale data set on the growth and asexual reproduction of two freshwater planarian… 
Let it rip: the mechanics of self-bisection in asexual planarians determines their population reproductive strategies
It is found that three different species, Dugesia japonica, Girardia tigrina and Schmidtea mediterranea, have evolved three different mechanical solutions to self-bisect, and how each planarian species divides dictates how resources are split among its offspring.
Mechanics dictate where and how freshwater planarians fission
The results demonstrate that where and how a planarian rips itself apart during asexual reproduction can be fully explained through biomechanics.
Multi-Behavioral Endpoint Testing of an 87-Chemical Compound Library in Freshwater Planarians
The data and experience gained from this screen are used to propose guidelines for best practices when using planarians for toxicology screens, and it is shown that planarians are the most sensitive to pesticides with 16/16 compounds causing toxicity and the least sensitive to PAHs.


Birth Size and a Size-Independent Stochastic Term Determine Asexual Reproduction Dynamics in Freshwater Planarians
A model based on recent studies on the cell cycle of budding yeast finds that molecular noise in gene expression and cell size at birth together control cell cycle variability, and finds that such a model can indeed explain the observed distribution of waiting times between birth and next reproductive event.
Memory and obesity affect the population dynamics of asexual freshwater planarians
A detailed population study for the asexual freshwater planarian Schmidtea mediterranea, which can reproduce via transverse fission due to a large stem cell contingent, and a surprising result is the non-monotonic relationship between effective population growth rate and nutrient supply.
Entropy and Statistics of Asexual Reproduction in Freshwater Planarians
It is found that these flatworms adopt a randomized reproduction strategy thatises both asymmetric binary fission and fragmentation (generation of multiple offspring during a reproduction cycle) and suggests that certain characteristic aspects of the reproduction statistics can be explained in terms of a maximum relative entropy principle.
The More the Merrier ? Entropy and Statistics of Asexual Reproduction in Freshwater
This work investigates clonal reproduction in the freshwater planarian Schmidtea mediterranea, an important model organism for regeneration and stem cell research, and finds that these flatworms adopt a randomized reproduction strategy that comprises both asymmetric binary fission and fragmentation.
Sloppy size control of the cell division cycle.
Scaling laws governing stochastic growth and division of single bacterial cells
The experimental and theoretical analysis reveals a simple physical principle governing these complex biological processes: a single temperature-dependent scale of cellular time governs the stochastic dynamics of growth and division in balanced growth conditions.
Crossover in the dynamics of cell wall growth controls bacterial division times
This work investigates size control and the cell cycle dependence of bacterial growth, using multigenerational cell growth and shape data for single Caulobacter crescentus cells and reveals a biphasic growth mechanism: a timer phase before constriction, followed by an adder phase during constriction.
Concerted control of Escherichia coli cell division
This work introduces a quantitative method for estimating the variables controlling division rate and uses it to construct a minimal model from large-scale dynamic data on the size of dividing Escherichia coli cells, and quantifies cell division control using a stochastic model.
Regenerating the central nervous system: how easy for planarians!
  • F. Cebrià
  • Biology
    Development Genes and Evolution
  • 2007
Current knowledge on the planarian nervous system and the genes involved in its regeneration are discussed, and some of the important questions that remain to be answered are discussed.