Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino

@article{RosalesNieves2006CoordinationOM,
  title={Coordination of microtubule and microfilament dynamics by Drosophila Rho1, Spire and Cappuccino},
  author={Alicia E. Rosales-Nieves and James E. Johndrow and Lani C. Keller and Craig R. Magie and Delia Mar{\'i}a Pinto-Santini and Susan M Parkhurst},
  journal={Nature Cell Biology},
  year={2006},
  volume={8},
  pages={367-376}
}
The actin-nucleation factors Spire and Cappuccino (Capu) regulate the onset of ooplasmic streaming in Drosophila melanogaster. Although this streaming event is microtubule-based, actin assembly is required for its timing. It is not understood how the interaction of microtubules and microfilaments is mediated in this context. Here, we demonstrate that Capu and Spire have microtubule and microfilament crosslinking activity. The spire locus encodes several distinct protein isoforms (SpireA, SpireC… CONTINUE READING

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