Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis.

  title={Coordination of larval and prepupal gene expression by the DHR3 orphan receptor during Drosophila metamorphosis.},
  author={Geoffrey Tak-Kin Lam and Cai-Zhong Jiang and Carl S Thummel},
  volume={124 9},
The DHR3 orphan receptor gene is induced directly by the steroid hormone ecdysone at the onset of Drosophila metamorphosis. DHR3 expression peaks in early prepupae, as the early puff genes are repressed and betaFTZ-F1 is induced. Here we provide evidence that DHR3 directly contributes to both of these regulatory responses. DHR3 protein is bound to many ecdysone-induced puffs in the polytene chromosomes, including the early puffs that encode the BR-C and E74 regulatory genes, as well as the E75… CONTINUE READING


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