Coordination of interstrand cross-links between polydeoxyguanylic acid and polydeoxycytidylic acid by cis-diamminedichloroplatinum (II).

@article{Harder1983CoordinationOI,
  title={Coordination of interstrand cross-links between polydeoxyguanylic acid and polydeoxycytidylic acid by cis-diamminedichloroplatinum (II).},
  author={H C Harder and Chien Chung Lee},
  journal={Cancer research},
  year={1983},
  volume={43 10},
  pages={
          4799-804
        }
}
Cisplatin has been shown to create interstrand DNA crosslinks by several methods. These experiments were performed to determine if cisplatin coordinates cross-links between deoxyguanylic and deoxycytidylic acids. After incubation at pH 7.2 with cisplatin at various platinum/base nucleotide ratios, ri, for 3 days at 20 degrees, polydeoxyguanylic acid . polydeoxycytidylic acid [poly(dG) . poly(dC)] was centrifuged in alkaline cesium sulfate for 3 days at 35,000 rpm. Untreated samples resulted in… CONTINUE READING

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