Coordination of citric acid cycle activity with electron transport flux.

@article{Williamson1976CoordinationOC,
  title={Coordination of citric acid cycle activity with electron transport flux.},
  author={Joseph Williamson and Clark Ford and John Illingworth and Brian Safer},
  journal={Circulation research},
  year={1976},
  volume={38 5 Suppl 1},
  pages={I39-51}
}
Feedback control between flux through the phosphorylating electron transport chain and the coordination of flux through individual steps of the citric acid cycle have been investigated under a number of different conditions of substrate availability and workloads in the isolated perfused rat heart. The transition from substrate-free perfusion to perfusion with glucose and insulin with no change of workload was associated with increases in the pool sizes of citric acid cycle intermediates except… CONTINUE READING