Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.

@article{Fujiwara2001CoordinationOC,
  title={Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.},
  author={Hiromi Fujiwara and Toshiyuki Hamaoka},
  journal={International immunopharmacology},
  year={2001},
  volume={1 4},
  pages={613-23}
}
T cell migration into tumor masses is critical to the process of immunologically induced tumor regression. Like other lymphoid populations, T cells are recruited to inflammatory sites depending on the interaction of T cell integrin receptors with their ligands expressed on vasculature. It is increasingly becoming evident that the adhesive capacity of integrins is upregulated by signals from chemokine receptors. A model of intratumoral T cell migration has been established using IL-12 to induce… CONTINUE READING

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