Coordination of T cell activation and migration through formation of the immunological synapse.

@article{Dustin2003CoordinationOT,
  title={Coordination of T cell activation and migration through formation of the immunological synapse.},
  author={Michael L. Dustin},
  journal={Annals of the New York Academy of Sciences},
  year={2003},
  volume={987},
  pages={51-9}
}
T cell activation is based on interactions of T cell antigen receptors with MHC-peptide complexes in a specialized cell-cell junction between the T cell and antigen-presenting cell-the immunological synapse. The immunological synapse coordinates naïve T cell activation and migration by stopping T cell migration with antigen-presenting cells bearing appropriate major histocompatibility complex (MHC) peptide complexes. At the same time, the immunological synapse allows full T cell activation… CONTINUE READING