Coordination of Growth and Cell Division in the Drosophila Wing

@article{Neufeld1998CoordinationOG,
  title={Coordination of Growth and Cell Division in the Drosophila Wing},
  author={Thomas P Neufeld and Aida de la Cruz and Laura A. Johnston and Bruce A. Edgar},
  journal={Cell},
  year={1998},
  volume={93},
  pages={1183-1193}
}
In most tissues, cell division is coordinated with increases in mass (i.e., growth). To understand this coordination, we altered rates of division in cell clones or compartments of the Drosophila wing and measured the effects on growth. Constitutive overproduction of the transcriptional regulator dE2F increased expression of the S- and M-phase initiators Cyclin E and String (Cdc25), thereby accelerating cell proliferation. Loss of dE2F or overproduction of its corepressor, RBF, retarded cell… 
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