Coordinating tissue interactions: Notch signaling in cardiac development and disease.


The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the past centered on Notch function in cardiomyocytes. However, recent advances demonstrate that region-specific endocardial Notch activity orchestrates the patterning and morphogenesis of cardiac chambers and valves through regulatory interaction with multiple… (More)
DOI: 10.1016/j.devcel.2012.01.014


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