Coordinating assembly and export of complex bacterial proteins.

  title={Coordinating assembly and export of complex bacterial proteins.},
  author={Rachael L Jack and Grant Buchanan and Alexandra Dubini and Kostas Hatzixanthis and Tracy Palmer and Frank Sargent},
  journal={The EMBO journal},
  volume={23 20},
The Escherichia coli twin-arginine protein transport (Tat) system is a molecular machine dedicated to the translocation of fully folded substrate proteins across the energy-transducing inner membrane. Complex cofactor-containing Tat substrates, such as the model (NiFe) hydrogenase-2 and trimethylamine N-oxide reductase (TorA) systems, acquire their redox cofactors prior to export from the cell and require to be correctly assembled before transport can proceed. It is likely, therefore, that… CONTINUE READING
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