Coordinating ERK/MAPK signalling through scaffolds and inhibitors

  title={Coordinating ERK/MAPK signalling through scaffolds and inhibitors},
  author={Walter Kolch},
  journal={Nature Reviews Molecular Cell Biology},
The pathway from Ras through Raf and MEK (MAPK and ERK kinase) to ERK/MAPK (extracellular signal-regulated kinase/mitogen-activated protein kinase) regulates many fundamental cellular processes. Recently, a number of scaffolding proteins and endogenous inhibitors have been identified, and their important roles in regulating signalling through this pathway are now emerging. Some scaffolds augment the signal flux, but also mediate crosstalk with other pathways; certain adaptors target MEK–ERK… CONTINUE READING
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