Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells.

@article{Kreda2007CoordinatedRO,
  title={Coordinated release of nucleotides and mucin from human airway epithelial Calu-3 cells.},
  author={Silvia M. Kreda and Seiko F. Okada and Catharina A van Heusden and Wanda O'neal and Sherif Gabriel and Lubna H. Abdullah and Christiana W Davis and Richard C. Boucher and Eduardo Rodolfo Lazarowski},
  journal={The Journal of physiology},
  year={2007},
  volume={584 Pt 1},
  pages={
          245-59
        }
}
The efficiency of the mucociliary clearance (MCC) process that removes noxious materials from airway surfaces depends on the balance between mucin secretion, airway surface liquid (ASL) volume, and ciliary beating. Effective mucin dispersion into ASL requires salt and water secretion onto the mucosal surface, but how mucin secretion rate is coordinated with ion and, ultimately, water transport rates is poorly understood. Several components of MCC, including electrolyte and water transport, are… CONTINUE READING