Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin.

@article{Feng2012CoordinatedRO,
  title={Coordinated regulation of murine cardiomyocyte contractility by nanomolar (-)-epigallocatechin-3-gallate, the major green tea catechin.},
  author={Wei Feng and Hyun Seok Hwang and Dmytro O. Kryshtal and Tao Yang and Isela T Padilla and Asheesh K Tiwary and Birgit Puschner and Isaac N Pessah and Bj{\"o}rn C Knollmann},
  journal={Molecular pharmacology},
  year={2012},
  volume={82 5},
  pages={993-1000}
}
Green tea polyphenolic catechins exhibit biological activity in a wide variety of cell types. Although reports in the lay and scientific literature suggest therapeutic potential for improving cardiovascular health, the underlying molecular mechanisms of action remain unclear. Previous studies have implicated a wide range of molecular targets in cardiac muscle for the major green tea catechin, (-)-epigallocatechin-3-gallate (EGCG), but effects were observed only at micromolar concentrations of… CONTINUE READING
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Potential role of green tea catechins in various disease therapies : progress and promise

  • M Näbauer, G Callewaert, L Cleemann, M Morad
  • Clin Exp Pharmacol Physiol
  • 2012

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