Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.

@article{Georges2008CoordinatedRO,
  title={Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215.},
  author={Sara A. Georges and Matthew C. Biery and S Kim and Janell M. Schelter and Jane Guo and Aaron N. Chang and Aimee L Jackson and Michael O. Carleton and Peter S. Linsley and Michele A. Cleary and B. Nelson Chau},
  journal={Cancer research},
  year={2008},
  volume={68 24},
  pages={10105-12}
}
Cell cycle arrest in response to DNA damage is an important antitumorigenic mechanism. MicroRNAs (miRNAs) were recently shown to play key regulatory roles in cell cycle progression. For example, miR-34a is induced in response to p53 activation and mediates G(1) arrest by down-regulating multiple cell cycle-related transcripts. Here we show that genotoxic stress promotes the p53-dependent up-regulation of the homologous miRNAs miR-192 and miR-215. Like miR-34a, activation of miR-192/215 induces… CONTINUE READING
Highly Influential
This paper has highly influenced 14 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS