Coordinated regulation of ammonium assimilation and carbon catabolism by glyoxylate in Saccharomyces cerevisiae.

  title={Coordinated regulation of ammonium assimilation and carbon catabolism by glyoxylate in Saccharomyces cerevisiae.},
  author={A. Gonz{\'a}lez and Luis Rodr{\'i}guez and Jorge Luis Folch and Mario Sober{\'o}n and H. Olivera},
  journal={Journal of general microbiology},
  volume={133 9},
The activities of citrate synthase (EC and NADP+-dependent glutamate dehydrogenase (GDH) (EC of Saccharomyces cerevisiae were inhibited in vitro by glyoxylate. In the presence of glyoxylate, pyruvate and glyoxylate pools increased, suggesting that glyoxylate was efficiently transported and catabolized. Pyruvate accumulation also indicates that citrate synthase was inhibited. A decrease in the glutamate pool was also observed under these conditions. This can be attributed to an… 

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