Coordinated regulation of NK receptor expression in the maturing human immune system.

@article{StraussAlbee2014CoordinatedRO,
  title={Coordinated regulation of NK receptor expression in the maturing human immune system.},
  author={Dara M Strauss-Albee and Amir Horowitz and Peter R Parham and Catherine A. Blish},
  journal={Journal of immunology},
  year={2014},
  volume={193 10},
  pages={4871-9}
}
NK cells are responsible for recognizing and killing transformed, stressed, and infected cells. They recognize a set of non-Ag-specific features termed "altered self" through combinatorial signals from activating and inhibitory receptors. These NKRs are also expressed on CD4(+) and CD8(+) T cells, B cells, and monocytes, although a comprehensive inventory of NKR expression patterns across leukocyte lineages has never been performed. Using mass cytometry, we found that NKR expression patterns… CONTINUE READING
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