Coordinated regulation of 23S rRNA maturation in Escherichia coli.

@article{Gutgsell2010CoordinatedRO,
  title={Coordinated regulation of 23S rRNA maturation in Escherichia coli.},
  author={Nancy S Gutgsell and Chaitanya Jain},
  journal={Journal of bacteriology},
  year={2010},
  volume={192 5},
  pages={1405-9}
}
In Escherichia coli, rRNAs are transcribed as precursors and require processing at the 3' and 5' ends to generate mature RNA molecules. The largest of these RNAs, 23S rRNA, is matured at the 3' end by a set of exonucleases and at the 5' end by an unknown RNase. Whether the 3' and 5' maturation steps occur independently or are coupled has previously been unclear. By assessing the levels of precursors accumulating at the 3' and 5' ends, we provide evidence that these processes may be linked. Thus… CONTINUE READING