Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses.

@article{Wacher2007CoordinatedRA,
  title={Coordinated regulation and widespread cellular expression of interferon-stimulated genes (ISG) ISG-49, ISG-54, and ISG-56 in the central nervous system after infection with distinct viruses.},
  author={Christie Wacher and Marcus Mueller and Markus J Hofer and Daniel R. Getts and Regina Zabaras and Shalina S Ousman and Fulvia Terenzi and Ganes C Sen and Nicholas J C King and Iain L Campbell},
  journal={Journal of virology},
  year={2007},
  volume={81 2},
  pages={860-71}
}
The interferon (IFN)-stimulated genes (ISGs) ISG-49, ISG-54, and ISG-56 are highly responsive to viral infection, yet the regulation and function of these genes in vivo are unknown. We examined the simultaneous regulation of these ISGs in the brains of mice during infection with either lymphocytic choriomeningitis virus (LCMV) or West Nile virus (WNV). Expression of the ISG-49 and ISG-56 genes increased significantly during LCMV infection, being widespread and localized predominantly to common… CONTINUE READING
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Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3 , NFB , and interferon but not Toll - like receptor 3

  • G. Geiss, G. Jin, J. Guo, R. Bumgarner, M. G. Katze, G. C. Sen
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