Coordinated protein sorting, targeting and distribution in polarized cells

@article{Mellman2008CoordinatedPS,
  title={Coordinated protein sorting, targeting and distribution in polarized cells},
  author={Ira Mellman and W. James Nelson},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={833-845}
}
The polarized distribution of functions in polarized cells requires the coordinated interaction of three machineries that modify the basic mechanisms of intracellular protein trafficking and distribution. First, intrinsic protein-sorting signals and cellular decoding machineries regulate protein trafficking to plasma membrane domains; second, intracellular signalling complexes define the plasma membrane domains to which proteins are delivered; and third, proteins that are involved in cell–cell… CONTINUE READING