Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma.

@article{Jayson1999CoordinatedMO,
  title={Coordinated modulation of the fibroblast growth factor dual receptor mechanism during transformation from human colon adenoma to carcinoma.},
  author={Gordon C. Jayson and Cristina Vives and Chris Paraskeva and Kevin Schofield and Janelle Coutts and Andrew Fleetwood and John Thomas Gallagher},
  journal={International journal of cancer},
  year={1999},
  volume={82 2},
  pages={298-304}
}
Basic fibroblast growth factor (bFGF) is dependent on heparan sulphate for its ability to activate the cell surface signal transducing receptor. We have investigated the FGF dual receptor mechanism in a novel model of the transformation from human colon adenoma to carcinoma in vitro. Reverse transcription-polymerase chain reaction showed that mRNA for FGF receptors 1 and 2 were expressed in both the adenoma and carcinoma cells whereas immunocytochemistry showed that the expression of the FGF R1… CONTINUE READING
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