Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.

@article{Upadhyay2011CoordinatedME,
  title={Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.},
  author={Anup K Upadhyay and John R. Horton and Xing Zhang and Xiaodong Cheng},
  journal={Current opinion in structural biology},
  year={2011},
  volume={21 6},
  pages={750-60}
}
Both components of chromatin (DNA and histones) are subjected to dynamic postsynthetic covalent modifications. Dynamic histone lysine methylation involves the activities of modifying enzymes (writers), enzymes removing modifications (erasers), and readers of the epigenetic code. Known histone lysine demethylases include flavin-dependent monoamine oxidase lysine-specific demethylase 1 and α-ketoglutarate-Fe(II)-dependent dioxygenases containing Jumonji domains. Importantly, the Jumonji domain… CONTINUE READING