Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.

@article{Araki2004CoordinatedMO,
  title={Coordinated metabolism of Alcadein and amyloid beta-protein precursor regulates FE65-dependent gene transactivation.},
  author={Yoichi Araki and Naomi Miyagi and Naoko Asano Kato and Tomohiro Yoshida and Sachiyo Wada and Masaki Nishimura and Hiroto Komano and Tohru Yamamoto and Bart De Strooper and Kazuo Yamamoto and Toshiharu Suzuki},
  journal={The Journal of biological chemistry},
  year={2004},
  volume={279 23},
  pages={24343-54}
}
The Alcadeins (Alcs)/calsyntenins and the amyloid beta-protein precursor (APP) associate with each other in the brain by binding via their cytoplasmic domains to X11L (the X11-like protein). We previously reported that the formation of this APP-X11L-Alc tripartite complex suppresses the metabolic cleavages of APP. We show here that the metabolism of the… CONTINUE READING