Coordinated integrin activation by actin-dependent force during T-cell migration

@inproceedings{Nordenfelt2016CoordinatedIA,
  title={Coordinated integrin activation by actin-dependent force during T-cell migration},
  author={Pontus Nordenfelt and Hunter Elliott and Timothy A Springer},
  booktitle={Nature communications},
  year={2016}
}
For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ligands. However, the role this force plays in integrin activation is unknown. Here we show that integrin activity and cytoskeletal dynamics are reciprocally linked, where actin-dependent force itself appears to regulate integrin activity. We generated fluorescent tension-sensing… CONTINUE READING
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