Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells.

@article{Ishikawa1996CoordinatedIO,
  title={Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells.},
  author={Toru Ishikawa and J J Bao and Yoshiaki Yamane and Kunihiro Akimaru and K Frindrich and Clifford D. Wright and Marcus Tien Kuo},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 25},
  pages={14981-8}
}
We recently reported that GS-X pump activity, as assessed by ATP-dependent transport of the glutathione-platinum complex and leukotriene C4, and intracellular glutathione (GSH) levels were remarkably enhanced in cis-diamminedichloroplatinum(II) (cisplatin)-resistant human leukemia HL-60 cells (Ishikawa, T., Wright, C. D., and Ishizuka, H. (1994) J. Biol. Chem. 269, 29085-29093). Now, using Northern hybridization and RNase protection assay, we provide evidence that the multidrug resistance… CONTINUE READING

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