Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

@article{Meresse2004CoordinatedIB,
  title={Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.},
  author={B. Meresse and Zhangguo Chen and C. Ciszewski and M. Tretiakova and G. Bhagat and T. Krausz and D. Raulet and L. Lanier and V. Groh and T. Spies and E. Ebert and P. Green and B. Jabri},
  journal={Immunity},
  year={2004},
  volume={21 3},
  pages={
          357-66
        }
}
  • B. Meresse, Zhangguo Chen, +10 authors B. Jabri
  • Published 2004
  • Biology, Medicine
  • Immunity
  • A major function of NKG2D linking innate and adaptive immunity is to upregulate antigen-specific CTL-mediated cytotoxicity in tissues expressing stress-induced NKG2D ligands, such as MIC, by coactivating TCR signaling. Here, we show that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling pathway leading to ERK and JNK activation are coordinately primed to activate direct… CONTINUE READING
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