Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.

@article{Meresse2004CoordinatedIB,
  title={Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease.},
  author={Bertrand Meresse and Zhangguo Chen and Cezary Ciszewski and Maria M Tretiakova and Govind Bhagat and Thomas Krausz and David H Raulet and Lewis L. Lanier and Veronika Groh and Thomas Spies and Ellen Catherine Ebert and Peter H. R. Green and Bana Jabri},
  journal={Immunity},
  year={2004},
  volume={21 3},
  pages={
          357-66
        }
}
A major function of NKG2D linking innate and adaptive immunity is to upregulate antigen-specific CTL-mediated cytotoxicity in tissues expressing stress-induced NKG2D ligands, such as MIC, by coactivating TCR signaling. Here, we show that, under conditions of dysregulated IL15 expression in vivo in patients with celiac disease and in vitro in healthy individuals, multiple steps of the NKG2D/DAP10 signaling pathway leading to ERK and JNK activation are coordinately primed to activate direct… CONTINUE READING
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