Coordinated histone modifications mediated by a CtBP co-repressor complex

  title={Coordinated histone modifications mediated by a CtBP co-repressor complex},
  author={Yujiang Geno Shi and Jun-ichi Sawada and Guangchao Sui and El Bachir Affar and Johnathan R. Whetstine and Fei Lan and Hidesato Ogawa and Margaret Po-shan Luke and Yoshihiro Nakatani and Yang Shi},
The transcriptional co-repressor CtBP (C-terminal binding protein) is implicated in tumorigenesis because it is targeted by the adenovirus E1A protein during oncogenic transformation. Genetic studies have also identified a crucial function for CtBP in animal development. CtBP is recruited to DNA by transcription factors that contain a PXDLS motif, but the detailed molecular events after the recruitment of CtBP to DNA and the mechanism of CtBP function in tumorigenesis are largely unknown. Here… CONTINUE READING