Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.

@article{Clayburgh2006CoordinatedEN,
  title={Coordinated epithelial NHE3 inhibition and barrier dysfunction are required for TNF-mediated diarrhea in vivo.},
  author={Daniel R. Clayburgh and Mark W Musch and Michael Leitges and Yang-Xin Fu and Jerrold R Turner},
  journal={The Journal of clinical investigation},
  year={2006},
  volume={116 10},
  pages={
          2682-94
        }
}
Acute T cell-mediated diarrhea is associated with increased mucosal expression of proinflammatory cytokines, including the TNF superfamily members TNF and LIGHT. While we have previously shown that epithelial barrier dysfunction induced by myosin light chain kinase (MLCK) is required for the development of diarrhea, MLCK inhibition does not completely restore water absorption. In contrast, although TNF-neutralizing antibodies completely restore water absorption after systemic T cell activation… CONTINUE READING

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The tumor necrosis factor (TNF) family member LIGHT causes actomyosin-dependent occludin endocytosis and barrier dysfunction

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