Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.

@article{Wiklund2011CoordinatedER,
  title={Coordinated epigenetic repression of the miR-200 family and miR-205 in invasive bladder cancer.},
  author={Erik D. Wiklund and Jesper Bertram Bramsen and Toby Hulf and Lars Dyrskj\ot and Ramshanker Ramanathan and Thomas B Hansen and Sune B. Villadsen and Shan Gao and Marie Stampe Ostenfeld and Michael Borre and Marcus E Peter and Torben F. \Orntoft and J\orgen Kjems and Susan J. Clark},
  journal={International journal of cancer},
  year={2011},
  volume={128 6},
  pages={1327-34}
}
MicroRNAs (miRNA) are small noncoding RNAs commonly deregulated in cancer. The miR-200 family (miR-200a, -200b, -200c, -141 and -429) and miR-205 are frequently silenced in advanced cancer and have been implicated in epithelial to mesenchymal transition (EMT) and tumor invasion by targeting the transcriptional repressors of E-cadherin, ZEB1 and ZEB2. ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop, but otherwise little is known about the transcriptional… CONTINUE READING
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Urinary BladderIs associated anatomic site ofBladder Neoplasm
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Here we report concerted transcriptional regulation of the miR-200 and miR-205 loci in bladder tumors and bladder cell lines .
Using a combination of miRNA expression arrays , qPCR assays and mass spectrometry DNA methylation analyses , we show that the miR-200 and miR-205 loci are specifically silenced and gain promoter hypermethylation and repressive chromatin marks in muscle invasive bladder tumors and undifferentiated bladder cell lines .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Here we report concerted transcriptional regulation of the miR-200 and miR-205 loci in bladder tumors and bladder cell lines .
Using a combination of miRNA expression arrays , qPCR assays and mass spectrometry DNA methylation analyses , we show that the miR-200 and miR-205 loci are specifically silenced and gain promoter hypermethylation and repressive chromatin marks in muscle invasive bladder tumors and undifferentiated bladder cell lines .
Urinary BladderIs associated anatomic site ofCarcinoma of bladder
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Urinary BladderIs primary anatomic site of diseaseCarcinoma of bladder
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Using a combination of miRNA expression arrays , qPCR assays and mass spectrometry DNA methylation analyses , we show that the miR-200 and miR-205 loci are specifically silenced and gain promoter hypermethylation and repressive chromatin marks in muscle invasive bladder tumors and undifferentiated bladder cell lines .
Here we report concerted transcriptional regulation of the miR-200 and miR-205 loci in bladder tumors and bladder cell lines .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
Moreover , we report that miR-200c expression is significantly correlated with early stage T1 bladder tumor progression , and propose miR-200 and miR-205 silencing and DNA hypermethylation as possible prognostic markers in bladder cancer .
ZEB1 is also known to repress miR-200c-141 transcription in a negative feedback loop , but otherwise little is known about the transcriptional regulation of the miR-200 family and miR-205 .
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