Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila.

  title={Coordinated control of dCTCF and gypsy chromatin insulators in Drosophila.},
  author={Tatiana I. Gerasimova and Elissa P. Lei and Ashley M. Bushey and Victor G Corces},
  journal={Molecular cell},
  volume={28 5},
CTCF plays a central role in vertebrate insulators and forms part of the Fab-8 insulator in Drosophila. dCTCF is present at hundreds of sites in the Drosophila genome, where it is located at the boundaries between bands and interbands in polytene chromosomes. dCTCF colocalizes with CP190, which is required for proper binding of dCTCF to chromatin, but not with the other gypsy insulator proteins Su(Hw) or Mod(mdg4)2.2. Mutations in the CP190 gene affect Fab-8 insulator activity, suggesting that… CONTINUE READING

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