Coordinated action of protein tyrosine phosphatases in insulin signal transduction.

  title={Coordinated action of protein tyrosine phosphatases in insulin signal transduction.},
  author={Alan Nai-Jen Cheng and Nadia Dub{\'e} and Feng Gu and Michel L Tremblay},
  journal={European journal of biochemistry},
  volume={269 4},
Insulin is the principal regulatory hormone involved in the tight regulation of fuel metabolism. In response to blood glucose levels, it is secreted by the beta cells of the pancreas and exerts its effects by binding to cell surface receptors that are present on virtually all cell types and tissues. In humans, perturbations in insulin function and/or secretion lead to diabetes mellitus, a severe disorder primarily characterized by an inability to maintain blood glucose homeostasis. Furthermore… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 36 extracted citations

Insulin signaling and glucose homeostasis in mice lacking protein tyrosine phosphatase alpha.

Biochemical and biophysical research communications • 2004
View 8 Excerpts
Highly Influenced

Corosolic acid stimulates glucose uptake via enhancing insulin receptor phosphorylation.

Lei Shi, Wei Zhang, +4 authors Jia Li
European journal of pharmacology • 2008
View 2 Excerpts
Highly Influenced

Osmotic regulation of bile acid transport, apoptosis and proliferation in rat liver.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2011

Similar Papers

Loading similar papers…