Coordinated action of protein tyrosine phosphatases in insulin signal transduction.

@article{Cheng2002CoordinatedAO,
  title={Coordinated action of protein tyrosine phosphatases in insulin signal transduction.},
  author={Alan Nai-Jen Cheng and Nadia Dub{\'e} and Feng Gu and Michel L Tremblay},
  journal={European journal of biochemistry},
  year={2002},
  volume={269 4},
  pages={1050-9}
}
Insulin is the principal regulatory hormone involved in the tight regulation of fuel metabolism. In response to blood glucose levels, it is secreted by the beta cells of the pancreas and exerts its effects by binding to cell surface receptors that are present on virtually all cell types and tissues. In humans, perturbations in insulin function and/or secretion lead to diabetes mellitus, a severe disorder primarily characterized by an inability to maintain blood glucose homeostasis. Furthermore… CONTINUE READING

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